The influence of partial replacement of titanium by vanadium on the structure and phase composition of the cast Ti$_{45.5}$Zr$_{30}$Mn$_{22.5}$V$_{2}$ alloy and on the kinetic parameters of hydrogenation and dehydrogenation processes is studied. As established, the vanadium introduction does not affect the sorption of hydrogen at the first hydrogenation cycle, however, the temperature of hydrogen desorption reduced by 25°C. The alloy activated by the first sorption—desorption cycle is capable for hydrogen absorption even at room temperature and a pressure of 0.23 MPa. As shown, the bulk alloy can be crushed into the powder with average particle size of $\cong$ 80 $\mu$m by two cycles of sorption—desorption + sorption.