In this paper, the results of atomic force microscopy are used to investigate the surface topology and structure of condensates of copper, aluminium, and chromium on the (111) plane of monocrystalline silicon substrates with the characteristic thicknesses d: 2.5, 10, 50, and 100 nm. A cluster statistical analysis of obtained condensates’ surface is performed by means of the Hoshen—Kopelman algorithm; the character geometric parameters of cluster nanoformations are determined. For studied metals, the energy parameters of interphase interactions in the ‘metallic condensate—silicon’ system, such as energy of interface interaction, interfacial tension, adhesive bond energy and the work of adhesion, are estimated using macroscopic approach based on the relations of the surface non-equilibrium thermodynamics and physics. Differences in the morphology of metallic condensates on silicon are substantiated.