The structural-phase state, magnetoresistive and magnetic properties of three-layer film systems based on permalloy (Py) and silver, obtained by the method of alternate condensation, are studied in this work. For as-deposited films and annealed at 600 K ones, the phase composition corresponds to f.c.c.-Ag and f.c.c.-Ni(Fe) with a lattice parameter of 0.4085–0.4095 nm and 0.359–0.361 nm, respectively. The phase state of the films annealed at the 800 K corresponds to f.c.c.-Ag and f.c.c.-Ni$_3$Fe. Studies of magnetoresistance show that spin-dependent electron scattering is realized in as-deposited systems with a silver layer (3–10 nm). After annealing three-layer films at 600 K, the transition from isotropic to the anisotropic character of the magnetoresistance is observed. The magnetic properties of films do not significantly depend on the thickness of the non-magnetic layer of silver. Annealing up to 800 K leads to an abrupt increase in the coercive force, which is caused by the phase transition of f.c.c.-Ni(Fe) → f.c.c.-Ni$_3$Fe and disruption of the structural continuity of the non-magnetic layer.