The relevance of the research is based on the development of nanometallurgy, which is an adequate response to the growing demand and expansion of the fields of application of nanoparticles of metallic oxides. Scientific and engineering thought is constantly searching for solutions to optimise and modernise the production of target nanosize metallic oxides that leads to the establishment of a significant scientific and informational landscape, which currently does not provide an unambiguous answer regarding the single methodology for obtaining the target product (in this case, nanosize magnesium oxide) that requires additional research and appropriate analytical conclusions. Therefore, the purpose of this study is to determine the technological method of manufacturing nanosize magnesium oxide, which has the most effective and competitive indicators, as well as to check the possibility of using digital modelling tools to optimise production processes in nanometallurgy. To achieve the formulated goal, the methods of digital modelling of the magnesium-oxide nanolattice and corresponding analytical conclusions and proposals are used in the current research. The study establishes that, among the seven typical methods of obtaining nanosize magnesium oxide (combustion in solution, co-precipitation, sol–gel, hydrothermal synthesis, solvothermal synthesis, sol–gel using microwaves, green synthesis), the most effective for the industrial production of the target nanomaterial are sol–gel and coprecipitation. The technological method of green synthesis of nanoparticles of metallic oxides (including nano-MgO) is also relevant, which is more ecological with competitive industrial and technological indicators of the production process. The conclusions obtained during the analysis of chronotaxometric schemes, which are the result of a bibliometric analysis of scientific studies and publications on the leading scientometric resources, indicate an increase in the variability of possible areas of use and production of metallic oxides in nanoforms, which indicates the dynamic and extensive stage of development of nanometallurgy. Digital modelling of the desired magnesium-oxide nanolattice helps to optimise the technological process and can be involved in the industrial field of nanometallurgy as a design stage. The practical value of the study is to obtain a correlative systematisation of various technologies for obtaining magnesium-oxide nanoparticles and to assess the impact of the design and modelling stage on the development of nanometallurgy in general.