The paper presents a generalization of the Martin—Erdélyi—Beke kinetic mean-field method for vacancy diffusion mechanism within the quasistationary approximation of vacancies. The simulation of spinodal decomposition with using the generalized method for the two-dimensional and three-dimensional cases is made. The dependences of the spinodal decomposition parameters (characteristic inhomogeneity and deviation of concentration) on the mobilities of components and on the asymmetry coefficient are presented. The exponential-growth rate of the deviation is determined by the slow component and is practically independent on the initial noise in the system.